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Friday, February 9 • 9:15am - 10:30am
Antifungal activity clove oil has when combined with Amphotericin B against fungus known to cause Mucormycosis, Rhizopus oryzae.

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Previous antifungal research involving Rhizopus oryzae has focused on planktonic
cells alone and not on biofilm formation and treatment. This is problematic due to
the increased antifungal resistance seen when treating bacterial and fungal biofilm
compared to planktonic cells. The species Rhizopus oryzae is known to cause up to
80% of all Mucormycosis infections. Amp B is the current line of treatment for this
disease, but is known to have many negative side effects such as being severely toxic to the liver and kidney and causing fever, shaking, and
nausea. The basis of the experiment is to
investigate the antifungal properties of clove oil and amphotericin B (amp B) against
fungal biofilm produced from the species Rhizopus oryzae. By using amp B and
clove oil synergistically, less amp B would be needed to observe the same amount
of cell death than when using each antifungal agent alone. This research has
important clinical application that could potentially impact the lives of those
suffering from this rare, opportunistic disease.


Friday February 9, 2018 9:15am - 10:30am
Great Hall Conference Center

Attendees (2)